Table 3.

Plasma levels of the 4 cardiovascular biomarkers under study before and after PMC, in the overall population and according to procedural success

	Whole population (N = 40)			Successful PMC (n = 30)			Unsuccessful PMC (n = 10)
	Pre-PMC	Post-PMC	pvalue	Pre-PMC	Post-PMC	pvalue	Pre-PMC	Post-PMC	pvalue
BNP, pg/mL	182 [80–194]	132 [56–125]	0.028	184 [63–194]	122 [53–123]	0.03	176 [87–193]	161 [60–344]	0.62
NT-proBNP, pg/mL	1050[232–1171]	739 [219–909]	0.08	1067 [200–1171]	654 [141–706]	0.08	999 [311–1128]	994 [375–1951]	0.97
MR-proANP, nmol/mL	220 [142–273]	187 [130–224]	0.0025	219 [142–257]	179 [123–219]	0.0012	223 [139–284]	210 [133–347]	0.6
sCD146, ng/mL	379 [308–441]	343[277–416]	0.0081	370 [298–427]	327 [268–378]	0.002	406 [323–483]	389 [283–555]	0.7

PMC percutaneous mitral commissurotomy. P-values are for the comparison before vs after by paired Student t test

Reference values for middle-aged women: BNP < 100 pg/ml, NT-proBNP< 300 pg/mL, MR-proANP< 85 nmol/mL, sCD146 still under investigation, likely < 320 ng/mL