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. 2019 Jul 25;30(3):1016–1029. doi: 10.1093/cercor/bhz144

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© The Author(s) 2019. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of site-specific pharmacological inactivation on feedback sensitivity and reward collection latency in the deterministic touchscreen serial visual reversal task. Effects of site-specific pharmacological inactivation on the probability to make a correct response after a loss (A) and after a win (B) as well as on latencies to collect earned food reward (C). mOFC inactivation enhanced the sensitivity to negative feedback (trend toward increased lose-shift) and decreased latencies to collect earned food rewards. In contrast, lOFC inactivation produced a diminished sensitivity to both positive and negative feedbacks as well as slower magazine latencies. Results are represented as mean ± SEM; **P < 0.01; *P < 0.05; #P < 0.1.