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. 2019 Oct 30;30(3):1688–1707. doi: 10.1093/cercor/bhz196

Figure 6.

Figure 6

IN-specific Reelin knockout mice showed normal general behavior and intact learning and memory function. (A) Assessment of the distance traveled over a 40 min test session shows unaltered locomotor habituation (time bins: F(4.21,113.56) = 32.6, P < 0.0001), but overall more activity in Cre-positive Relnwt/wt mice (genotype: F(2,27) = 7.52, P < 0.01). Activity levels were comparable between IN-specific Reelin knockout and Cre-negative Relnfl/fl mice (Bonferonni correction pairwise comparisons: P = 1.0). Anxiety-related behavior in terms of time spent in the center of the OF (B) and open arms of the elevated plus maze (EPM) (C) is unaltered in IN-specific Reelin knockout mice. One-way ANOVA (OF: F(2, 29) = 0.79, P = 0.46; EPM: F(2, 29) = 0.089, P = 0.92). N = 10 mice per group. (D–E) In the MWM task, IN-specific Reelin knockout mice demonstrate intact spatial reference memory acquisition (days: F (9, 234) = 37.27, P < 0.0001; genotype: F(2, 26) = 0.62, P = 0.54) and subsequent time-dependent bias for the training quadrant (delay: F (1.49,38.62) = 22.86, P < 0.0001; genotype: F(2, 26) = 1.93, P = 0.17). N = 9–10 mice per group. All values represent mean ± SEM.