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. 2020 Apr 5;26:27. doi: 10.1186/s10020-020-00158-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — TFPI2 was down-regulated in breast cancer tissues and cell lines. a The expression of TFPI2 was down-regulated in breast cancer (Tumor) compared to normal breast specimens (Normal). ** represents Tumor vs. Normal tissues, P < 0.01. b Immunohistochemistry of TFPI2 in Normal, Non-metastasis or metastasis breast cancer tissues, suggesting down-regulation of TFPI2 in breast cancer tissues. c The expression of TFPI2 was down-regulated in human breast cancer cell lines (MDA-MB-453, MDA-MB-468 and MCF7) compared to CCD-1095Sk and MCF 10A. *, ** represents breast cancer cell lines vs. CCD-1095Sk, P < 0.05, P < 0.01