Table 3.
Association between systolic BP parameters and LVH (in cross-section) in unadjusted and adjusted analyses along with model discrimination
| Systolic BP Metrics (n=533) | Unadjusted OR (95% CI)a | Unadjusted c-Statistic (95% CI) | Adjusted OR (95% CI)a,b | Adjusted c-Statistic (95% CI)b |
|---|---|---|---|---|
| Awake systolic BP load (every 10% higher) | 1.1 (1.0 to 1.3) | 0.61 (0.53 to 0.68)c | 1.1 (1.0 to 1.3) | 0.77 (0.72 to 0.83)c |
| Awake systolic BP index (every 0.1 higher) | 1.7 (1.2 to 2.3) | 0.62 (0.55 to 0.69) | 1.6 (1.1 to 2.3) | 0.78 (0.73 to 0.83) |
| Awake systolic BP load plus awake systolic BP index | 0.9 (0.7 to 1.2) 2.4 (1.0 to 5.6) |
0.62 (0.55 to 0.69) | 0.8 (0.6 to 1.1) 2.7 (1.0 to 7.2) |
0.78 (0.73 to 0.84) |
| Asleep systolic BP load (every 10% higher) | 1.1 (1.0 to 1.2) | 0.62 (0.55 to 0.69)c | 1.1 (1.0 to 1.2) | 0.77 (0.72 to 0.83)c |
| Asleep systolic BP index (every 0.1 higher) | 1.5 (1.1 to 2.0) | 0.63 (0.56 to 0.70) | 1.5 (1.1 to 2.0) | 0.78 (0.72 to 0.83) |
| Asleep systolic BP load plus asleep systolic BP index | 0.9 (0.8 to 1.2) 1.8 (0.9 to 3.6) |
0.63 (0.56 to 0.71) | 0.9 (0.7 to 1.2) 1.8 (0.8 to 3.9) |
0.78 (0.72 to 0.83) |
LVH, left ventricular hypertrophy; OR, odds ratio.
a
OR for every 0.1 higher systolic BP index or 10% higher systolic BP load.
b
Adjusted for age, sex, race, cause of CKD, body mass index z-score, urine protein-creatinine ratio, antihypertensive use, and baseline eGFR (by bedside Schwartz), n=515 included due to missing covariates.
c
Reference group for awake or asleep c-statistic comparisons.