Table 4.
Association between systolic BP parameters and ESKD in unadjusted and adjusted analyses along with model discrimination
| Systolic BP Metrics (n=533) | Unadjusted HR (95% CI)a | Unadjusted c-Statistic (95% CI) | Adjusted HR (95% CI)a,b | Adjusted c-Statistic (95% CI)b |
|---|---|---|---|---|
| Awake systolic BP load (every 10% higher) | 1.2 (1.1 to 1.2) | 0.60 (0.54 to 0.65)c | 1.1 (1.0 to 1.1) | 0.89 (0.86 to 0.91)c |
| Awake systolic BP index (every 0.1 higher) | 1.6 (1.3 to 1.9) | 0.60 (0.55 to 0.65) | 1.2 (1.0 to 1.5) | 0.89 (0.86 to 0.91) |
| Awake systolic BP load plus awake systolic BP index | 1.1 (1.0 to 1.3) 1.2 (0.7 to 1.9) |
0.60 (0.55 to 0.67) | 0.9 (0.7 to 1.0) 1.8 (1.1 to 3.2) |
0.89 (0.85 to 0.91) |
| Asleep systolic BP load (every 10% higher) | 1.1 (1.0 to 1.2) | 0.58 (0.52 to 0.64)c | 1.0 (1.0 to 1.0) | 0.88 (0.85 to 0.91)c |
| Asleep systolic BP index (every 0.1 higher) | 1.4 (1.1 to 1.6) | 0.57 (0.52 to 0.63) | 1.2 (1.0 to 1.4) | 0.89 (0.85 to 0.91) |
| Asleep systolic BP load plus asleep systolic BP index | 1.1 (0.9 to 1.2) 1.1(0.7 to 1.7) |
0.58 (0.52 to 0.64) | 1.0 (0.8 to 1.1) 1.3 (0.9 to 2.1) |
0.88 (0.85 to 0.91) |
HR, hazard ratio.
a
HR reported for every 0.1 higher in systolic BP index or 10% higher systolic BP load.
b
Adjusted for age, sex, race, cause of CKD, body mass index z-score, duration of CKD, urine protein-creatinine ratio, serum albumin, hemoglobin, antihypertensive use, and baseline eGFR (by bedside Schwartz), n=515 included due to missing covariates.
c
Reference group for awake or asleep c-statistic comparisons.