Table 2.
Features of 15 TB antigens identified as putative biomarkers by serological screening of mini-protein microarrays.
| Locus tag-Ab type | ATB/LTBI+HC | P value | Gene symbol | Gene product description |
|---|---|---|---|---|
| MT1560.1-IgM | 1.040 | 0.0368 | MT1560.1 | Hypothetical protein |
| Rv0049-IgM | 1.014 | 0.037 | Rv0049 | Hypothetical protein |
| Rv0270-IgM | 1.017 | 0.0096 | fadD2 | Fatty-acid-CoA ligase FadD2 |
| Rv0350-IgG | 1.047 | 0.0462 | dnaK | Chaperone protein DnaK (HSP70) |
| Rv0350-IgM | 1.083 | 0.014 | dnaK | Chaperone protein DnaK (HSP70) |
| Rv0494-IgM | 1.002 | 0.016 | Rv0494 | HTH-type transcriptional regulator |
| Rv1597-IgM | 1.066 | 0.0012 | Rv1597 | Hypothetical protein |
| Rv1860-IgG | 1.144 | 0 | apa | Alanine and proline rich secreted protein Apa |
| Rv1876-IgM | 1.083 | 0 | bfrA | Bacterioferritin BfrA |
| Rv2031c-IgG | 1.023 | 0.0045 | hspX | Heat shock protein HspX |
| Rv2352c-IgM | 1.060 | 0.0002 | PPE38 | PPE family protein PPE38 |
| Rv2450c-IgM | 1.051 | 0.0284 | rpfE | Resuscitation-promoting factor RpfE |
| Rv2511-IgG | 1.036 | 0.0007 | orn | Oligoribonuclease Orn |
| Rv2688c-IgM | 1.056 | 0.0081 | Rv2688c | Antibiotic ABC transporter ATP-binding protein |
| Rv3480c-IgM | 1.049 | 0.0028 | Rv3480c | Diacylglycerol O-acyltransferase |
Ab, antibody; ABC, ATP-binding cassette; ATB, active TB; ATP, adenosine triphosphate; Co-A: coenzyme A; HC, healthy control; HSP, heat shock protein; IgG, immunoglobulin G; IgM, immunoglobulin M; LTBI: latent TB infection; PPE, Pro-Pro-Glu; and TB, tuberculosis.