Table 3.

Diagnostic parameters of 15 serum biomarkers for discriminating ATB from LTBI.

Locus tag-Ab type	Genesymbol	AUC (95% CI)	P value	Sensitivity (%)	Specificity (%)
MT1560.1-IgG	epiA	0.62 (0.542–0.698)	<0.001	40.6	82.5
Rv0049-IgM	Rv0049	0.673 (0.598–0.749)	<0.001	52.1	80.6
Rv0270-IgM	fadD2	0.582 (0.502–0.662)	<0.001	43.8	74.8
Rv0350-IgG	DnaK	0.56 (0.48–0.641)	<0.001	60.4	53.4
Rv0350-IgM	DnaK	0.607 (0.529–0.685)	<0.001	77.1	44.7
Rv0494-IgM	Rv0494	0.566 (0.486–0.646)	<0.001	74.0	40.8
Rv1597-IgM	Rv1597	0.635 (0.558–0.713)	<0.001	83.3	43.7
Rv1860-IgG	apa	0.665 (0.588–0.742)	<0.001	36.5	99.0
Rv1876-IgM	BfrA	0.64 (0.563–0.717)	<0.001	61.5	63.1
Rv2031c-IgG	HspX	0.521 (0.439–0.602)	<0.001	16.7	94.2
Rv2352c-IgM	PPE38	0.729 (0.658–0.799)	<0.001	66.7	72.8
Rv2450c-IgM	RpfE	0.61 (0.532–0.689)	<0.001	81.2	42.7
Rv2511-IgG	Orn	0.646 (0.569–0.722)	<0.001	63.5	65.0
Rv2688c-IgM	Rv2688c	0.577 (0.496–0.658)	<0.001	53.1	67.0
Rv3480c-IgM	Rv3480c	0.614 (0.536–0.692)	<0.001	85.4	36.9

95% CI, 95% confidence interval; Ab, antibody; ATB, active TB; AUC, area under the ROC curve; IgG, immunoglobulin G; IgM, immunoglobulin M; LTBI: latent TB infection; ROC, receiver operating characteristic; and TB, tuberculosis.