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. 2020 Mar 27;48(3):0300060520904861. doi: 10.1177/0300060520904861

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© The Author(s) 2020

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Figure 5. — Propofol regulates NK cell activity via the SMAD4 pathway.

(a, b) Western blot analysis of the effect of propofol on SMAD4 protein levels in NK cells under different culture conditions. (c) Western blot analysis for detecting the interference effects of SMAD4. (d) Restoration effect of propofol on GZMB expression in NK cells after SMAD4 interference. Experiments were performed in triplicate. *P<0.05, compared with the NC group. NK: natural killer; NC: normal control; TGF-β1: transforming growth factor-β1; GZMB: granzyme B; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; siR-SMAD4: small interfering RNA targeting Smad4; tSMAD4: total SMAD4.