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. 2020 Mar 26;30(2):117–128. doi: 10.1089/nat.2019.0807

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© Joanna Macdonald et al. 2020; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 8. — Brain distribution of aptamer or aptamer-DOX conjugates following tail vein injection. Brains were excised 60 and 75 min postintravenous administration, postfixed in 4% PFA, cryoprotected in 20% sucrose at 4°C overnight, sectioned, and imaged using laser scanning confocal microscopy. Representative images of three mice/group. Green: GFP tumor; red: TYE665-labeled bifunctional aptamer; and yellow: DOX. Arrow indicates areas of colocalization of aptamer and tumor cell (A) or aptamer-DOX and tumor cell (B). Scale bar: 20 μM. Color images are available online.