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Binding Affinity of Bifunctional Aptamer-Doxorubicin Conjugates to the Transferrin Receptor and Epithelial Cell Adhesion Molecule
| Aptamer | bEnd.3 (Kd), nM | MDA-MB-231 (Kd), nM | HEK293T (Kd), nM |
|---|---|---|---|
| TEPP | 110 ± 22.0 | 85.6 ± 28.5 | >10,000 |
| TEPP-DOX | 119 ± 30.7 | 536 ± 306 | >10,000 |
| TENN | >10,000 | >10,000 | >10,000 |
| TENN-DOX | 865 ± 439 | >10,000 | >10,000 |
DOX, doxorubicin.
Source: Macdonald et al. [25].
