Table 2.
Changes in Protein Expression in Sepsis vs. Control Patients
| Protein | Fold Change (Sepsis/Control) | P Value |
|---|---|---|
| Histidine-rich glycoprotein | 0.43 | 0.001 |
| Immunoglobulin heavy constant γ 2 | 0.50 | 0.003 |
| Immunoglobulin heavy constant γ 4 | 0.44 | 0.005 |
| Ig λ-2 chain C regions | 0.49 | 0.006 |
| Immunoglobulin heavy constant γ 1 | 0.49 | 0.012 |
| Immunoglobulin heavy constant γ 3 | 0.51 | 0.014 |
| Complement C4-A | 0.64 | 0.016 |
| Coagulation factor XI | 0.61 | 0.016 |
| Kallikrein | 0.15 | 0.018 |
| Complement C4-B | 0.67 | 0.020 |
| C-reactive protein | 1.53 | 0.024 |
| Immunoglobulin κ variable 1-33 | 0.50 | 0.024 |
| Immunoglobulin λ-like polypeptide 5 | 0.33 | 0.028 |
| Clusterin | 0.48 | 0.031 |
| Immunoglobulin heavy constant αj 1 | 0.64 | 0.039 |
| Complement C3 | 0.48 | 0.040 |
| Selenoprotein P | 0.20 | 0.047 |
| Plasminogen | 0.47 | 0.048 |
| Albumin | 0.95 | 0.812 |
| Actin | 8.00 | 0.351 |
Eighteen proteins were differentially expressed when patients with sepsis were compared with control patients. Of the 18 proteins, 17 were down-regulated and one, C-reactive protein, was up-regulated.