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(A) Apelin-13 attenuated cardiac fibrosis (blue) in MI rats. (B) Apelin-13 reduced the mRNA levels of collagen I, collagen III, and TGF-β in the heart of MI rats. (C) Apelin-13 reduced the protein levels of collagen I, collagen III, and TGF-β in the heart of MI rats. The results are expressed as mean ± standard error (n=8). *P<0.05 versus the Sham + Saline group; #P<0.05 versus the MI + Saline group.
