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. 2013 Jul 11;2013(7):CD009241. doi: 10.1002/14651858.CD009241.pub3

Saunders 1989.

Methods Double blinded randomised controlled trial of oxytocin versus placebo.
Participants 226 Nulliparous women (108 intervention, 118 placebo) with epidural analgesia, 37‐42 weeks' gestation, singleton fetus in vertex presentation, fully dilated cervix, no oxytocin prior to randomisation.
Interventions Oxytocin (initial dose 2 mU/min increasing to maximum of 16 mU/min) versus placebo.
Outcomes Duration of second stage, mode of delivery, postpartum haemorrhage, fetal condition (Apgar scores, neonatal jaundice, nursery admission, cord pH).
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Described as random number allocation although sequencing not specified.
Allocation concealment (selection bias) Low risk Sheffield: infusions of oxytocin added to saline or saline alone were prepared by the pharmacy.
London: coded vials of oxytocin or saline alone were used which were added to the infusion by labour ward staff.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk All data accounted for.
Selective reporting (reporting bias) Unclear risk This cannot be assessed as there was no published protocol or trial registration.
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk Double blinded.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Not stated.
Other bias Low risk None identified.