Dutton 2002.

Methods	Randomised controlled trial
Participants	110 trauma patients >16, <55 years of age with blunt and penetrating injuries and in shock Mean age = 31 Exclusion: pregnancy, no pulse, head or spinal injury, known end‐organ ischaemic disease
Interventions	Bolus of fluids (plasma, Plasmalyte‐A and packed red blood cells) to maintain systolic blood pressure of >100mmHg (n=55) 1000ml less of fluids (plasma, Plasmalyte‐A and packed red blood cells) to maintain a lower blood pressure of 70mmHg (n=55)
Outcomes	duration of bleeding average ISS death
Notes	All patients maintained at a haematocrit of at least 25%. Results analysed as randomised on an intention‐to‐treat basis.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Low risk	Allocation by drawing the next numbered envelope from a batch of 20, thoroughly mixed but sequentially numbered envelopes