Table 3:
Dysregulated Biomarkers in “stable” SV Fontan patients as compared to age, gender and race matched controls. Biomarkers were significantly different in various organ systems as noted above.
| Case (n=44) | Control (n=32) | Fold Changes | P value Wilcoxon ranked sum | |||
|---|---|---|---|---|---|---|
| Median (pg/mL) | IQR (25th-75th percentile) | Median (pg/mL) | IQR (25th-75th percentile) | |||
| Inflammatory | ||||||
| IL-6 | 1.36 | 0.86,2.1 | 0.81 | 0.61, 1.41 | 1.69 | 0.011 |
| TNF-α* | 2.93 | 1.76, 2.85 | 0.57 | 0.17, 0.97 | 1.66 | <0.001 |
| GDF-15 | 908.47 | 675.71, 1383.68 | 545.77 | 450.885, 688.540 | 1.66 | <0.0001 |
| β2-microglobulin | 2.41 | 1.551, 3.406 | 1.419 | 1.086, 1.702 | 1.70 | 0.0006 |
| Cell mobilization | ||||||
| SDF1α | 178.45 | 0.01, 556.925 | 0.25 | 0.01,253.82 | 713.78 | 0.006 |
| Renal Function | ||||||
| uPAR | 258.105 | 201.77, 308.47 | 203.075 | 120.11, 312.61 | 11.17 | 0.022 |
| Cystatin c | 438261 | 404053, 481752 | 370323 | 322646, 426023 | 1.18 | <0.0001 |
| Neurohormonal Activation | ||||||
| Renin | 286.94 | 178.39, 721.42 | 148.5 | 88.36, 195.38 | 1.93 | <0.0001 |
| Cardiac Injury | ||||||
| Cardiac Troponin-I | 15.375 | 7.99, 24.4 | 3.6075 | 0.01, 16.47 | 4.26 | 0.0004 |
| Extracellular Matrix Turnover | ||||||
| Collagen-IVa | 1633.31 | 864.65, 4138.67 | 497.53 | 362.555,805.335 | 3.34 | <0.0001 |
| Metabolism Regulator | ||||||
| Adiponectin | 15.583 | 8.09, 39.013 | 8.831 | 5.676, 14.327 | 1.76 | 0.0037 |
*
TNF-α was tested in a random subset of 23 patients.