Figure 2.

Workflow of PBPK model development for AT‐RvD1. The PBPK model for human with SS refers to the virtual population of the subjects whose anatomical physiological parameters reflect that of someone with SS. If the model‐predicted data does not agree with the observed experimental data, a parameter identification and optimization will be performed using the default tools provided by the PK‐Sim® software to identify the parameter responsible for the lack of accurate predicts and then its value will be optimized using the observed data until a goodness of fit is achieved between predicted versus observed data. AT‐RvD1, aspirin‐triggered resolvin D1; PBPK, physiologically based pharmacokinetic; PK, pharmacokinetics; SS, Sjögren's syndrome