Table 2.
Anatomical and physiological parameters of NOD‐ShiLtJ mice and humans
| Parameter | NOD/ShiLtJ mouse | Ref. | Human | Ref. |
|---|---|---|---|---|
| Average weight | 27.5 g | (Laboratory, 2018a) | 80.35 kg | (NHANES, 1997) |
| Body mass index (BMI) | N/A | 25.22 kg/m2 | (NHANES, 1997) | |
| Hematocrit | 0.45 | (Davies & Morris, 1993) | 0.45 | (Davies & Morris, 1993) |
| Organ blood flow rate (L/min) | PK‐Sim® default | (Edginton, Schmitt, & Willmann, 2006) | ||
| Brain | 0.00017 | 0.78 | ||
| Heart | 0.000366 | 0.26 | ||
| Kidney | 0.0017 | 1.32 | ||
| Liver | 0.000458 | 0.42 | ||
| Lung | 0.00711 | 6.25 | ||
| Spleen | 0.00018 | 0.17 | ||
| Organ volumes (ml) | PK‐Sim® default | PK‐Sim® default | ||
| Brain | 0.22 | 1,509.06 | ||
| Heart | 0.12 | 416.52 | ||
| Kidney | 0.45 | 437.33 | ||
| Liver | 1.70 | 2,366.5 | ||
| Lung | 0.13 | 1,210.12 | ||
| Spleen | 0.13 | 206.38 | ||
| Saliva | 0.00226 | 6.6 |
Abbreviation: PK, pharmacokinetics.