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. 2020 Mar 30;11:254. doi: 10.3389/fgene.2020.00254

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Copyright © 2020 Niu, Song, Wang and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mendelian randomization analyses of serum uric acid level on risk of multiple sclerosis. Abbreviations: CI = confidence interval; OR = odds ratio; IMSGC = International Multiple Sclerosis Genetics Consortium; IMSGC/WTCCC2 = The International Multiple Sclerosis Genetics Consortium and the Wellcome Trust Case Control Consortium 2; SNP = single-nucleotide polymorphism; IVW = inverse variance weighted. Cochran’s Q values for all SNPs, proxy SNPs excluded, outlier SNPs excluded, SNPs from IMSGC, and SNPs from IMSGC/WTCCC2 were 40.9 (p = 9.6 × 10^–4), 23.2 (p = 3.2 × 10^–3), 19.9 (p = 0.17), 19.5 (p = 0.01), and 49.3 (p = 5.5 × 10^–5), respectively. The intercepts in the MR-Egger regression are 0.0070 (SE = 0.0097, p = 0.48), 0.0052 (SE = 0.0212, p = 0.81), −0.0017 (SE = 0.0077, p = 0.83), 0.0095 (SE = 0.0138, p = 0.51), −0.0006 (SE = 0.0113, p = 0.96).