Summary of findings 2. Different doses of GnRHa depot compared to GnRHa daily injection for pituitary down regulation in assisted reproduction cycles.
| Different doses of GnRHa depot compared to GnRHa daily injection for pituitary down regulation in assisted reproduction cycles | ||||||
| Patient or population: patients with pituitary down regulation in assisted reproduction cycles Settings: outpatients Intervention: different doses of GnRHa depot Comparison: GnRHa daily injection | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| GnRHa daily injection | Different doses of GnRHa depot | |||||
| Number of gonadotrophin (FSH) units employed ‐ half dose | The mean number of gonadotrophin (FSH) units employed in the control groups using half dose ranged from 1942 to 3448 IU | The mean number of gonadotrophin (FSH) units employed in the intervention groups using half dose was 0.24 standard deviations higher (0.11 lower to 0.6 higher) | 616 (5 studies) | ⊕⊝⊝⊝ very low1,2,3 | SMD 0.24 (‐0.11 to 0.6) | |
| Number of gonadotrophin (FSH) units employed ‐ full dose | The mean number of gonadotrophin (FSH) units employed in the control groups using full dose ranged from 1260 to 3195 IU | The mean number of gonadotrophin (FSH) units employed in the intervention groups using full dose was 0.28 standard deviations higher (0.11 to 0.45 higher) | 527 (6 studies) | ⊕⊕⊝⊝ low1,3 | SMD 0.28 (0.11 to 0.45) | |
| Number of days of gonadotrophin treatment ‐ half dose | The mean number of days of gonadotrophin treatment in the control groups using half dose ranged from 8.6 to 10.58 days | The mean number of days of gonadotrophin treatment in the intervention groups using half dose was 0.64 higher (0.36 to 0.92 higher) | 507 (4 studies) | ⊕⊕⊝⊝ low1,2 | ||
| Number of days of gonadotrophin treatment ‐ full dose | The mean number of days of gonadotrophin treatment in the control groups using full dose ranged from 8.26 to 10.9 days | The mean number of days of gonadotrophin treatment in the intervention groups using full dose was 0.66 higher (0.41 to 0.92 higher) | 526 (6 studies) | ⊕⊕⊝⊝ low1,2 | ||
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; FSH: follicle‐stimulating hormone; GnRHa: gonadotrophin‐releasing hormone agonist; IU: international units; SMD: standardised mean difference | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1 Most of the studies were classified as having an unclear risk of bias for all domains. 2 Unexplained heterogeneity. 3 Considerable differences detected in standard deviations among studies.