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. Author manuscript; available in PMC: 2020 Apr 6.
Published in final edited form as: Neuropharmacology. 2016 Mar 5;107:160–167. doi: 10.1016/j.neuropharm.2016.03.010

Fig. 1.

Fig. 1.

Schematic representation of the chimeric Kv3.1-Kv2.1 channels constructed. a) Overview of chimeras between Kv3.1 (white) and Kv2.1 (red). Specific parts of the gating machinery were transplanted from Kv2.1 into Kv3.1, yielding functional channels when expressed in Ltk− cells. b) Sequence alignment of Kv3.1 and Kv2.1 S1-S6 region. Parts that are exchanged are indicated by arrows. Note that the S1-S4 and S1-S3a chimeras contained an additional Asn to Glu mutation (*) since this residue is crucial for the interaction between S1 and the pore helix (Lee et al., 2009). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)