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. Author manuscript; available in PMC: 2020 Apr 6.
Published in final edited form as: Neuropharmacology. 2016 Mar 5;107:160–167. doi: 10.1016/j.neuropharm.2016.03.010

Fig. 3.

Fig. 3.

Biophysical properties and TEA/flecainide affinity of the different VSD chimeras. a) Normalized conductance versus voltage GV relationships which show the voltage dependence of channel activation of WT Kv3.1 (white circles, n = 5), WT Kv2.1 (white triangles, n = 4) and the different chimeras Kv3.1_EMcoupling_2.1 (gray inverted triangles, n = 7), Kv3.1_S1-S4_2.1 (gray circles, n = 5), Kv3.1_S1-S3a_2.1 (black circles, n = 5), and Kv3.1_S3b-S4_2.1 (black triangles, n = 5). b) Time constants of channel activation for WT channels and various chimeras plotted as a function of voltage (meaning of symbols is the same as panel a). c) Panel shows for WT Kv3.1 and the different VSD chimeras the IC50 value ± S.E.M. of current inhibition by external TEA (top) or Flecainide (bottom). Note that there is no significant difference in the IC50 values of the VSD chimeras compared to WT Kv3.1, which indicates that the VSD chimeras displayed a similar TEA and Flecainide drug sensitivity as WT Kv3.1.