3. Template for 'Summary of findings' table.
| Anticoagulants plus antiplatelet agents versus antiplatelet agents for asymptomatic carotid stenosis | ||||||
|
Patient or population: adults with asymptomatic carotid stenosis Settings: community Intervention: anticoagulants plus antiplatelet agents Comparison: antiplatelet agents | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Risk with antiplatelet agents | Risk with anticoagulants plus antiplatelet agents | |||||
| [control] | [experimental] | |||||
| Neurological impairment | [mean difference] (CI) | [mean difference] (CI) | _ | [value] ([value]) |
⊕⊝⊝⊝
very low ⊕⊕⊝⊝ low ⊕⊕⊕⊝ moderate ⊕⊕⊕⊕ high |
|
| Ipsilateral major or disabling stroke | [value] per 1000 | [value] per 1000 ([value] to [value]) | RR [value] ([value] to [value]) | [value] ([value]) |
⊕⊝⊝⊝
very low ⊕⊕⊝⊝ low ⊕⊕⊕⊝ moderate ⊕⊕⊕⊕ high |
|
| Stroke‐related mortality | [value] per 1000 | [value] per 1000 ([value] to [value]) | RR [value] ([value] to [value]) | [value] ([value]) |
⊕⊝⊝⊝
very low ⊕⊕⊝⊝ low ⊕⊕⊕⊝ moderate ⊕⊕⊕⊕ high |
|
| Major bleeding | [value] per 1000 | [value] per 1000 ([value] to [value]) | RR [value] ([value] to [value]) | [value] ([value]) |
⊕⊝⊝⊝
very low ⊕⊕⊝⊝ low ⊕⊕⊕⊝ moderate ⊕⊕⊕⊕ high |
|
| Progression of carotid stenosis | [value] per 1000 | [value] per 1000 ([value] to [value]) | RR [value] ([value] to [value]) | [value] ([value]) |
⊕⊝⊝⊝
very low ⊕⊕⊝⊝ low ⊕⊕⊕⊝ moderate ⊕⊕⊕⊕ high |
|
| Adverse events | [value] per 1000 | [value] per 1000 ([value] to [value]) | RR [value] ([value] to [value]) | [value] ([value]) |
⊕⊝⊝⊝
very low ⊕⊕⊝⊝ low ⊕⊕⊕⊝ moderate ⊕⊕⊕⊕ high |
|
| Quality of life | [value] per 1000 | [value] per 1000 ([value] to [value]) | RR [value] ([value] to [value]) | [value] ([value]) |
⊕⊝⊝⊝
very low ⊕⊕⊝⊝ low ⊕⊕⊕⊝ moderate ⊕⊕⊕⊕ high |
|
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RR: risk ratio | ||||||
| GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Further research is very unlikely to change our confidence in the estimate of effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. We are very uncertain about the estimate. | ||||||