Figure 2:

Experimental protocol for blood and tissue sampling in vivo. The animals in each experimental group underwent a 10-minute intra-arterial infusion of doxorubicin (DOX) (2 mg/mL, 100 mL) at 0 and 120 minutes. Prior to administration of the second dose of DOX in group 2, ChemoFilter (CF) devices were deployed. Blood samples were collected at various timepoints during each treatment for pharmacokinetic analysis. After treatment, the pigs were euthanized and tissue analysis was performed. IAC = intraarterial chemotherapy.