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ChemoFilter Devices Decrease Systemic Exposure and Peak Doxorubicin Concentration
Note.—Pharmacokinetic parameters of doxorubicin in vivo after multiple intraarterial chemotherapy (IAC) administrations. Data were from the systemic blood samples. AUC = area under the curve, CF = ChemoFilter, Cmax = concentration maximum. ΔCmax = change in Cmax from second IAC minus first IAC. ΔAUC systemic = [(AUCinj2 − AUCinj1)/AUCinj1] × 100 (ie, change in AUC systemic from second IAC minus first IAC).
