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. 2004 Oct 15;11(10):1445–1453. doi: 10.1016/j.chembiol.2004.08.011

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Copyright © 2004 Elsevier Ltd. All rights reserved.

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Dose-Response Curves for the Five Secondary Hits from the Screening Campaign

IC₅₀ values were extracted from the curves using nonlinear regression analysis (see Experimental Procedures). IC₅₀ values for the five secondary hits were 0.5 ± 0.3 μM (MAC-5576), 4.3 ± 0.5 μM (MAC-8120), 7 ± 2 μM (MAC-13985), 2.6 ± 0.4 μM (MAC-22272), and 7 ± 3 μM (MAC-30731). The corresponding structure of each compound is shown on each dose-response curve.