Date	Event	Description
19 September 2017	New citation required but conclusions have not changed	Sherie Smith has been added to the author list. Changes have been made throughout most sections of the review, although the conclusions remain unchanged.
19 September 2017	New search has been performed	The trial previously listed as ongoing is now included (Olujohungbe 2011). A further trial has been included in the review (Burnett 2014). A total of three trials (102 participants) are included in the review. These trials compare stilboestrol to placebo, sildenafil to placebo and ephedrine or etilefrine to placebo. The review has been updated throughout and four new summary of findings tables have been added.
27 August 2010	New search has been performed	A search of the Group's Haemoglobinopathies Trials Register did not identify any trials potentially relevant for inclusion in the review.
4 September 2008	Amended	Converted to new review format.
4 September 2008	New search has been performed	A search of the Group's Haemoglobinopathies Trials Register identified no new trials eligible for inclusion in the review.
1 February 2008	Amended	A new Plain Language Summary has replaced the previous Synopsis.
1 February 2008	New search has been performed	A search of the Group's Haemoglobinopathies Trials Register identified no new trials eligible for inclusion in the review.
1 February 2007	New search has been performed	A search of the Group's Haemoglobinopathies Trials Register identified no new trials eligible for inclusion in the review.
1 December 2005	New search has been performed	A search of the Group's Haemoglobinopathies Trials Register identified no new trials eligible for inclusion in the review.