ChiCTR1800017370.

Trial name or title	Clinical effects of oral administration of ethylphenylephrine and sildenafil for preventing penile erectile dysfunction in people with sickle cell anemia.
Methods	RCT, parallel design.
Participants	Males aged 20 ‐ 45 years with SCD and at least two obvious penile erection episodes per week.
Interventions	Ethylphenylephrine intervention group: receiving 30 mg of ephedrine per day; Sildenafil intervention group: receiving sildenafil 50 mg once daily; Control group: only deals with acute attacks that last more than 4 hours.
Outcomes	Primary outcome: reduction of priapism episodes bi‐weekly from baseline. Secondary outcomes: average duration of an abnormal erection documented biweekly; hospitalisations due to persistent erection.
Starting date	Date registered: 26 July 2018 Date of first enrolment: 1 June 2018
Contact information	Rui‐Zhi Xue ‐ docfrankhsueh@csu.edu.cn Zheng‐Yan Tang ‐ doczhengyantang@163.com Xiangya Hospital of Central South University
Notes	Last updated 26 July 2018

RCT: randomised controlled trial
 SCD: sickle cell disease