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. 2007 Aug 30;370(9589):786–796. doi: 10.1016/S0140-6736(07)61382-8

Figure 4.

Figure 4

Effect of salmeterol (100 μg/day), fluticasone (1000 μg/day), both (combination), or placebo on the mean number of moderate and severe exacerbations of COPD per year, over 3 years

*p<0·001 vs placebo. †p=0,002 vs salmeterol. ‡p=0·024 vs fluticasone. Adapted with permission from Calverley and colleagues.93