Fig 4. Effects of smoke exposure and sex on different alpha diversity metrics in mice cecal content.

Comparisons of different alpha diversity metrics between male (n = 20), female (n = 20) and ovariectomized females (n = 18) mice (A-D) and after stratification by smoking exposure and sex (E-H) are shown. P-values were obtained using the Kruskal-Wallis test (*), and the Benjamini-Hochberg method was applied to compute adjusted p-values for multiple pairwise comparisons. ASV = amplicon sequence variant, Faith’s PD = Faith’s Phylogenetic Diversity, CM = control male, SM = smoke-exposed male, CF = control female, SF = smoke-exposed female, COF = ovariectomized control female, and SOF = ovariectomized smoke-exposed female.