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. 2020 Apr 2;13:2783–2793. doi: 10.2147/OTT.S232769

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© 2020 Ye et al.

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Upregulation of SPRY4-IT1 and downregulation of MPZL-1 induced EMT reversal.

Notes: (A) The expressions of Vimentin and E-cadherin were detected by qRT-PCR in A549/DDP cells transfected with si-MPZL-1 and NC at 24 h after treatment. (B) The expressions of Vimentin and E-cadherin were detected by Western blot in A549/DDP cells transfected with si-MPZL-1 and NC. (C) The expressions of Vimentin and E-cadherin were detected by qRT-PCR in A549/DDP cells transfected with pCDNA-SPRY4-IT1 and NC at 24 h after treatment. (D) The expressions of Vimentin and E-cadherin were detected by Western blot in A549/DDP cells transfected with pCDNA-SPRY4-IT1 and NC at 24 h after treatment. **P<0.01.

Abbreviations: EMT, epithelial–mesenchymal transition; RT-qPCR, quantitative real-time polymerase chain reaction; SPRY4-IT1, SPRY4 intronic transcript 1.