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. 2020 Apr 2;13:2783–2793. doi: 10.2147/OTT.S232769

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© 2020 Ye et al.

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Overexpression of SPRY4-IT1 enhanced cisplatin sensitivity of NSCLC cell in vivo.

Notes: (A) Tumor formed of A549/DDP cells transfected with pCDNA/SPRY4-IT1 after cisplatin treatment was inhibited in vivo. (B and C) Tumor weight and volume of A549/DDP cells transfected with pCDNA/NC and pCDNA/SPRY4-IT1 after cisplatin treatment in vivo. (D) qRT-PCR was used to detect the SPRY4-IT1 expression in pCDNA/NC and pCDNA/SPRY4-IT1 group. (E) The E-cadherin, Vimentin and Ki-67 expressions were detected by IHC. **P<0.01.

Abbreviations: SPRY4-IT1, SPRY4 intronic transcript 1; RT-qPCR, quantitative real-time polymerase chain reaction; IHC, Immunohistochemistry.