Table 1. Characteristics for the total cohort, triglyceride and total cholesterol groups.
| Total cohort | Triglyceride levels at time of ALL-diagnosis N = 112 |
Total cholesterol levels at time of ALL-diagnosis N = 112 |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| N = 127 N (%) |
Normal triglyceride levels N = 47 N (%) |
Hypertriglyceridemia N = 65 N (%) |
P-value | Normal total cholesterol levels N = 91 N (%) |
Hypocholesterolemia N = 15 N (%) |
P-value (comparison between normal and hypocholesterolemia) | Hypercholesterolemia N = 6 N (%) |
P-value (comparison between normal and hypercholesterolemia) | |
| Variables at time of ALL-diagnosis | |||||||||
| Age group | 0.045 | 0.0017 | >0.99 | ||||||
| Children, Age <10 years | 95 (75) | 31 (66) | 54 (83) | 74 (81) | 6 (40) | 5 (83) | |||
| Adolescents, Age ≥10 years | 32 (25) | 16(34) | 11 (17) | 17 (19) | 9 (60) | 1 (17) | |||
| Sex | 0.25 | 0.78 | 0.035 | ||||||
| Male | 76 (60) | 30 (64) | 34 ((52) | 49 (54) | 9 (60) | 6 (100) | |||
| Female | 51 (40) | 17 (36) | 31 (48) | 42 (46) | 6 (40) | 0 (0) | |||
| BMI group | 0.71 | >0.99 | 0.68 | ||||||
| Lean (<90 percentile) | 105 (83) | 40 (85) | 53 (82) | 74 (81) | 13 (87) | 6 (100) | |||
| Overweight (≥90<99 percentile) | 17 (13) | 5 (11) | 10 (15) | 13 (14) | 2 (13) | 0 (0) | |||
| Obese (≥99 percentile) | 5 (4) | 2 (4) | 2 (3) | 4 (5) | 0 (0) | 0 (0) | |||
| Risk group at diagnosis | 0.65 | 0.30 | 0.0026 | ||||||
| Non-high risk | 100 (89) | 38(80) | 50 (77) | 73 (80) | 14 (93) | 1 (17) | |||
| High risk | 27 (21) | 9 (20) | 15 (23) | 18 (20) | 1 (7) | 5 (83) | |||
| Immunophenotype | >0.99 | >0.99 | 0.00017 | ||||||
| Pre B-cell precursor | 110 (87) | 41 (87) | 56 (86) | 82 (90) | 14 (93) | 1 (17) | |||
| T-cell | 17 (13) | 6 (13) | 9 (14) | 9 (10) | 1 (7) | 5 (83) | |||
| WBC group | 0.56 | 0.19 | 0.069 | ||||||
| <50 ×109/L | 93 (73) | 37 (79) | 46 (71) | 69 (76) | 11 (73) | 3 (50) | |||
| 50–100 ×109/L | 14 (11) | 3 (6) | 8 (12) | 6 (7) | 3 (20) | 2 (33) | |||
| ≥100 ×109/L | 20 (16) | 7 (15) | 11 (17) | 16 (17) | 1 (7) | 1 (17) | |||
| Mediastinal mass | 0.24 | >0.99 | 0.061 | ||||||
| No | 102 (94) | 43 (98) | 59 (91) | 84 (94) | 14 (100) | 4 (67) | |||
| Yes | 7 (6) | 1 (2) | 6 (9) | 5 (6) | 0 (0) | 2 (33) | |||
| Missing | 18 | 3 | 0 | 2 | 1 | 0 | |||
| Thrombocytes (109/L)^ | 54 (20−128) | 32 (15−87.5) | 0.086 | 40 (16–93) | 30 (14–91) | 0.74 | 69 (30–172) | 0.28 | |
| Leukocytes (109/L)^ | 6.7 (3.1−24.9) | 9.0 (5.3−49.0) | 0.13 | 8.3 (3.5−38.8) | 8.1 (3.9−30.0) | 0.69 | 44.7 (5.6−71.2) | 0.18 | |
| Hemoglobin (mmol/L)^ | 4.2 (3.0−4.9) | 4.4 (3.3−5.4) | 0.13 | 4.2 (3.1–5.2) | 4.5 (3.1–6.5) | 0.37 | 5.0 (4.3–5.2) | 0.36 | |
| C-reactive protein (mg/L)^ | 13 (3−33) | 10 (5−26) | 0.58 | 9 (3–29) | 16 (10–39) | 0.092 | 21 (13–32) | 0.14 | |
| Ferritin (μg/L)^ | 394 (275−560) | 257 (178−362) | 0.0015 | 287 (185–442) | 393 (264–925) | 0.031 | 300 (218–427) | 0.92 | |
| Sedimentation reaction (mm)^ | 74 (42−107) | 51 (24−80) | 0.038 | 54 (32–103) | 57 (25–105) | 0.67 | 50 (24–140) | 0.90 | |
| ALAT (U/L)^ | 15 (11−49) | 21 (14−38) | 0.30 | 19 (13–41) | 21 (14–38) | 0.57 | 15 (7–70) | 0.54 | |
| Bilirubin (μmol/L)^ | 5 (3−7) | 5 (3−8) | 0.87 | 4 (3–7) | 7 (5–10) | 0.0081 | 6 (4–10) | 0.25 | |
| Early treatment response | |||||||||
| Risk group end of induction | 0.24 | >0.99 | 0.024 | ||||||
| Standard risk | 61 (47) | 23 (49) | 29 (45) | 45 (50) | 7 (47) | 0 (0) | |||
| Intermediate risk | 50 (40) | 21 (45) | 24 (38) | 34 (38) | 6 (40) | 5 (83) | |||
| High risk | 15 (13) | 3 (6) | 11 (17) | 11 (12) | 2 (13) | 1 (17) | |||
| Missing (dead) | 1 | 0 | 1 | 1 | 0 | 0 | |||
| MRD at end of induction | 0.21 | 0.78 | >0.99 | ||||||
| No | 75 (69) | 35 (76) | 40 (65) | 61 (70) | 10 (67) | 4 (67) | |||
| Yes | 33 (31) | 11 (24) | 22 (35) | 26 (30) | 5 (33) | 2 (33) | |||
| Missing | 5 | 1 | 3 | 4 | 0 | 0 | |||
| Final risk group (Day 79) | 0.098 | 0.86 | 0.025 | ||||||
| Standard risk | 59 (45) | 23 (49) | 29 (46) | 45 (51) | 7 (47) | 0 (0) | |||
| Intermediate risk | 47(38) | 21 (45) | 21 (33) | 32 (36) | 5 (33) | 5 (83) | |||
| High risk | 19 (16) | 3 (6) | 13 (21) | 12 (13) | 3 (20) | 1 (17) | |||
| Missing (dead) | 2 | 0 | 2 | 2 | 0 | 0 | |||
| MRD at day 79 | 0.50 | 0.27 | >0.99 | ||||||
| No | 106 (98) | 42 (100) | 51 (96) | 76 (99) | 12 (92) | 5 (100) | |||
| Yes | 2 (2) | 0 (0) | 2 (4) | 1(1) | 1 (8) | 0 (0) | |||
| Missing | 19 | 5 | 12 | 14 | 2 | 1 | |||
P-values are from Fisher’s exact test. Abbreviations: BMI, body mass index; MRD, minimal residual disease; WBC, white blood cell count.
^Median and interquartile range, P-value from Wilcoxon two sample test.