Table 2. Cumulative incidences of toxicity.

		Thromboembolism		Osteonecrosis		Pancreatitis
	Total cohort N (%)	2.5-year cumulative incidence, % (95% CI)	P-value	2.5-year cumulative incidence, % (95% CI)	P-value	2.5-year cumulative incidence, % (95% CI)	P-value
Total	127	5.5 (2.4–10.5)		7.2 (3.5–12.7)		18.2 (12.1–25.4)
Age groups			0.26		0.55		0.32
Children, Age <10 years	95 (75)	4.2 (1.4–9.7)		6.4 (2.6–12.6)		20.1 (12.7–28.7)
Adolescents, Age ≥10 years	32 (25)	9.4 (2.3–22.5)		9.8 (2.4–23.6)		12.5 (3.9–26.5)
Triglyceride levels at time of ALL-diagnosis			0.67		0.63		0.32
Normal (<UNL)	47 (42)	6.4 (1.6–15.9)		8.6 (2.7–18.9)		12.8 (5.1–24.0)
Mild hypertriglyceridemia (≥UNL and <10xUNL)	65 (58)	4.6 (1.2–11.8)		6.3 (2.0–14.2)		20.0 (11.3–30.5)
Total cholesterol levels at time of ALL-diagnosis			0.0074		0.49		0.52
Hypocholesterolemia (<LNL)	15 (14)	20.0 (4.5–43.3)		13.3 (2.0–35.4)		20.0 (4.5–43.3)
Normal	91 (81)	2.2 (0.004–6.9)		6.7 (2.7–13.3)		17.6 (10.6–26.1)
Mild hypercholesterolemia (≥UNL and <10xUNL)	6 (5)	16.7 (4.8–54.9)		-		-
LDL levels at time of ALL-diagnosis			0.94		0.59		0.48
Decreased (<LNL)	15 (13)	6.7 (0.4–26.9)		13.3 (2.0–35.5)		26.7 (7.7–50.5)
Normal	96 (86)	5.2 (1.49–11)		6.4 (2.6–12.7)		15.6 (9.2–23.6)
Increased (≥UNL)	1 (1)	-		-		-
HDL levels at time of ALL-diagnosis			-		-		-
Normal	2 (2)	-		-		-
Decreased (<LNL)	110 (98)	5.5 (2.2–10.8)		7.4 (3.4–13.4)		17.3 (10.9–24.9)
BMI at time of ALL-diagnosis			0.83		-		0.51
Lean	105 (83)	4.8 (1.8–10.1)		8.1 (2.8–14.7)		17.4(10.8–25.3)
Overweight	17 (13)	5.9 (3.4–24.3)		-		17.7(4.1–39.1)
Obese	5 (4)	-		-		40.0 (3.1–78.6)

Lipids at time of ALL-diagnosis are available for 112 of the 127 patients. P-values are from Gray’s test. Abbreviations: UNL, upper normal limit; LNL, lower normal limit; CI, confidence interval; LDL, low density lipoprotein; HDL, high density lipoprotein; BMI, body mass index.