Table 3.
Rates of reported complications associated with vaccinia vaccinations (cases/million vaccination)
| Age (yrs) and status | Inadvertent inoculation | Generalized vaccinia | Eczema vaccinatum | Progressive vaccinia | Postvaccinial encephalitis | Total |
|---|---|---|---|---|---|---|
| Primary vaccination | ||||||
| ≤ 1 | 507.0 | 394.4 | 14.1 | — | 42.3 | 1549.3 |
| 1–4 | 577.3 | 233.4 | 44.2 | 3.2 | 9.5 | 1261.8 |
| 5–19 | 371.2 | 139.7 | 34.9 | — | 8.7 | 855.9 |
| ≥ 20 | 606.1 | 212.1 | 30.3 | — | — | 1515.2 |
| Overall rates | 529.2 | 241.5 | 38.5 | 1.5 | 12.3 | 1253.8 |
| Revaccination | ||||||
| ≤ 1 | — | — | — | — | — | — |
| 1–4 | 109.1 | — | — | — | — | 200.0 |
| 5–19 | 47.7 | 9.9 | 2.0 | — | — | 85.5 |
| ≥ 20 | 25.0 | 9.1 | 4.5 | 6.8 | — | 113.6 |
| Overall rates | 42.1 | 9.0 | 3.0 | 3.0 | — | 108.2 |
Data from Lane JM, Ruben FL, Neff JM, Millar JD. Complications of smallpox vaccination, 1968: results from 10 statewide surveys. J Infect Dis 1970;122:303–9.