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. 2020 Apr 6;15(4):e0231226. doi: 10.1371/journal.pone.0231226

Table 4. Factors associated with adverse event emergence.

Factor N % Adverse Event Emergence p-value ORa 95%CI p-value
N Adverse Event Incidence, %
Overall b 812 100.0 170 20.9
Patient Characteristic
Sex 0.090c
Male 248 31.5 43 17.3
Female 539 68.5 122 22.6
Age 0.244d
Mean 58 7.2 10 17.2
< 75 years 117 14.6 24 20.5
≥ 75 and < 80 years 227 28.3 44 19.4
≥ 80 and < 85 years 235 29.3 51 21.7
≥ 85 and < 90 years 164 20.5 39 23.8
Nursing care level 0.052c
Independent/Assistance Required/Nursing Care Levels I-II 454 58.7 87 19.2
Ⅲ - Ⅴ 320 41.3 80 25.0
Living Situation 0.395c
At home, alone 206 25.4 38 18.4
At home, with spouse 139 17.1 26 18.7
Home, living with someone else 129 15.9 33 25.6
Communal living with assisted care / Special nursing home 337 41.6 73 21.7
Number of drugs being taken at the first pharmacist home visit 0.019c
0 – 9 530 69.6 100 18.9 ref
10 - 231 30.4 61 26.4 1.51 (1.04, 2.19) 0.030
Treatment adherence at first pharmacist home visit 0.064c
Not adherent/only taking medication 1–2 times a week 167 21.2 27 16.2 0.562d 0.91 (0.55, 1.51) 0.717
Forgets to take medication 1–2 times a week 230 29.2 59 25.7 1.55 (1.03, 2.31) 0.034
Takes medication as directed 390 49.6 79 20.3 ref
Appropriateness of anti-dementia drug therapy 0.009e
Determined to be not appropriate 42 5.3 16 38.1 2.85 (1.46, 5.60) 0.002
Determined to be appropriate 753 94.7 147 19.5 ref

a: adjusted for sex and level of nursing care

b: Including subjects from whom responses were not obtained for each factor

c: Chi-square test

d: p for trend

e: Fisher's exact test