Table 1.
Second-generation and molecular group A streptococcus testing, US Food and Drug Administration approved
| Assay | Targets | Methodology | Turnaround Time, min | CLIA Waived | Pediatric References |
|---|---|---|---|---|---|
| BD Veritor System | Group A streptococci | Immunochromatographic assay | 5 | Yes | — |
| Quidel Sofia Strep A + FIA | Group A streptococci | Immunofluorescence-based lateral flow | 5 | Yes | Roper et al,2 2017 |
| Alere i Strep A | Group A streptococci | Isothermal nucleic acid amplification | 8 | Yes | Cohen et al,7 2015 |
| Roche cobas LiatStrep A Assay | Group A streptococci | Real-time PCR | 15 | Yes | Uhl & Patel,6 2016 |
| Cepheid Xpert Xpress Strep A Assay | Group A streptococci | Real-time PCR | 30 | No | — |
| Quidel Solana Strep Complete Assay | Group A, C, and G streptococci | Isothermal helicase-dependent amplification | 25 | No | — |
| Meridian illumigene Group A Strep | Group A streptococci | Loop-mediated isothermal amplification | <60 | No | Henson et al,3 2013; Felsenstein et al,4 2014 |
| DiaSorin Simplexa Group A Strep | Group A, C, and G streptococci | Real-time PCR | 60 | No | Tabb & Batterman,5 2016 |