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. Author manuscript; available in PMC: 2020 Aug 17.
Published in final edited form as: Nat Genet. 2020 Feb 17;52(3):247–253. doi: 10.1038/s41588-020-0579-4

Extended Data Fig. 3. Reproducibility of dynASE across heterozygous individuals for the same SNP.

Extended Data Fig. 3

Here we wanted to assess whether dynamic ASE replicates well in different heterozygous individuals for the same SNP. First, from the 561 dynASE events at 5% FDR we took the top 356 unique SNPs (ensuring one heterozygous individual per SNP), and then asked how do the P-values look in other heterozygous individuals for those 356 SNPs. (a) Qqplot depicting the observed P-values in the other heterozygous individuals (y-axis), compared to the expected uniform distribution of P-values (x-axis). (b) Next, within all 561 significant events at 5% FDR, we evaluated the correlation of betas for time (left) and time squared (right) for all pairwise combinations of heterozygous individuals for the same SNP, i.e. het1 and het2 in x and y axis labels.