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. Author manuscript; available in PMC: 2021 Mar 3.
Published in final edited form as: Circulation. 2019 Nov 21;141(9):712–724. doi: 10.1161/CIRCULATIONAHA.119.042502

Table 4.

Cumulative systolic and diastolic blood pressure in relation to cognition in midlife

Cognition Cumulative SBP per 1 SD higher β (95% CI) p-value Cumulative DBP per 1 SD higher β (95% CI) p-value
Memory domain
Model 1 −0.14 (−0.26, −0.02) 0.022 −0.13 (−0.24, −0.02) 0.022
Model 2 −0.16 (−0.30, −0.03) 0.015 −0.16 (−0.28, −0.04) 0.012
Executive domain
Model 1 −0.12 (−0.21, −0.02) 0.014 −0.06 (−0.14, 0.03) 0.213
Model 2 −0.12 (−0.22, −0.02) 0.021 −0.05 (−0.15, 0.04) 0.263
Attention domain
Model 1 −0.04 (−0.15, 0.07) 0.451 −0.02 (−0.12, 0.09) 0.773
Model 2 −0.04 (−0.16, 0.08) 0.548 −0.03 (−0.14, 0.09) 0.625
Global domain
Model 1 −0.12 (−0.20, −0.03) 0.007 −0.08 (−0.16, 0.003) 0.059
Model 2 −0.12 (−0.21, −0.03) 0.010 −0.08 (−0.17, 0.002) 0.057

β represents unstandardized regression coefficients.

Mean ± SD of executive, memory, attention and global domains were −0.01±0.7, −0.01±0.8, 0.02 ±0.8 and −0.02±0.6, respectively.

Model 1: Adjusted for age, sex, race and education.

Model 2: Adjusted for age, sex, race, education, body mass index, smoking status, prevalence of diabetes, total cholesterol and depression measured at Y30 examination.

Abbreviations: SBP: systolic blood pressure and DBP: diastolic blood pressure; SD: standard deviation.