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. 2020 Mar 26;11:204. doi: 10.3389/fpsyt.2020.00204

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Copyright © 2020 Uranova, Vikhreva, Rakhmanova and Orlovskaya

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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These micrographs from layer 5 of the prefrontal cortex show microglia adjacent to oligodendrocytes from control brain (A) and from the SPPS subgroup (B–D). “Resting” microglia (A). Ameboid (activated) microglia (B). Dystrophic changes in microglia and oligodendrocytes: cytoplasm vacuolation, damaged mitochondria, accumulation of lipofuscin granules (C, D). Microglial cytoplasm contacts with oligodendrocyte nucleus (B, C, *). Focal lysis (L) of cytoplasm of oligodendrocytes adjacent to microglia (C, D). Mg, microglia; Ol, oligodendrocyte, m, mitochondria (arrows); V, vacuole (arrows), Lg, lipofuscin granule (arrows). (Scale bars = 1 µm).