Table 2.

Effect of diagnosis on microglia adjacent to oligodendrocytes and on oligodendrocytes adjacent to microglia.

	Microglia adjacent to oligodendrocytes
	Controls (n=20)	Schizophrenia (n=21)	F(1,37)	p	Cohen’s d	Controls (n=20)	SPPS (n=12)	SPNS (n=9)	F(2,36)	p	Cohen’s d
	Mean±SEM	Mean±SEM				Mean±SEM	Mean±SEM	Mean±SEM			SPPS/ Controls	SPNS/ Controls
Areaofmicroglia(μm2)	18.92±0.01	19.61±0.9	0.26	0.615	0.20	18.92±0.01	18.95±0.9	20.49±1.7	0.88	0.424	0,01	0.43
Areaofnucleus (μm2)	10.14±3.6	10.19±0.5	<0.00	0.985	0.03	10.14±3.6	10.01±0.4	10.43±1.0	0.04	0.956	0,09	0.15
Areaofcytoplasm(μm2)	8.78±0.3	9.42±0.7	0.42	0.522	0.24	8.78±0.3	8.93±0.7	10.07±1.3	1.19	0.315	0,07	0.45
Nucleus/cytoplasmratio	1.95±1.7	1.95±0.2	0.01	0.913	0.01	1.95±1.7	1.95±0.3	1.96±0.3	0.15	0.863	0,00	0.02
Areaofmitochondria (μm2)	0.90±1.0	0.38±0.01	29.47	<0.001***	1.33	0.90±1.0	0.35±0.1	0.40±0.1	14.56	<0.001***	1,34	1.27
Vvofmitochondria (%)	10.15±1.3	3.77±0.5	50.98	<0.001***	1.50	10.15±1.3	3.37±0.8	4.31±0.7	25.33	<0.001***	1,53	1.49
N ofmitochondria	1.68±0.2	0.65±0.1	33.91	<0.001***	1.36	1.68±0.2	0.54±0.1	0.80±0.2	17.60	<0.001***	1,44	1.23
Areaofvacuoles (μm2)	0.85±0.7	1.57±0.2	7.27	<0.05*	0.77	0.85±0.7	1.69±0.3	1.41±0.3	4.11	<0.05*	0,88	0.76
Vvofvacuoles (%)	9.25±0.01	17.54±2.5	9.79	<0.01**	0.83	9.25±0.01	19.51±3.7	14.91±3.2	6.35	<0.01**	1,01	0.77
N ofvacuoles	1.70±0.1	3.20±0.5	6.19	<0.05*	0.72	1.70±0.1	3.48±0.8	2.81±0.7	3.75	<0.05*	0,84	0.67
Area of lipofuscin granules μm2)	0.21±0.1	0.56±0.1	11.96	<0.01**	1.09	0.21±0.1	0.61±0.1	0.49±0.1	5.81	<0.01**	1,28	1.08
Vvoflipofuscingranules (%)	1.80±1.0	5.28±0.9	13.10	<0.001***	0.99	1.8±1.0	6.03±1.3	4.29±1.0	7.01	<0.01**	1,15	0.99
N oflipofuscingranules	0.11±0.2	0.32±0.1	9.95	<0.01**	0.90	0.11±0.2	0.30±0.1	0.33±0.1	5.37	<0.01**	1,06	0.99
Cell density (N /mm2)	59.97±4.1	69.88±5.4	1.50	0.228	0.42	59.97±4.1	70.04±8.8	69.67±5.3	0.75	0.478	0,40	0.48
Oligodendrocytes adjacent to microglia
Areaofoligodendrocyte(μm2)	38.87±0.7	45.97±1.8	9.34	<0.01**	0.87	38.87±0.7	43.84±2.0	48.8±3.1	5.50	<0.01**	0,71	1.15
Areaofnucleus (μm2)	15.67±5.3	18.4±1.0	3.79	0.059	0.60	15.67±5.3	17.25±1.3	19.93±1.6	2.60	0.088	0,38	0.91
Areaofcytoplasm (μm2)	23.21±0.01	27.57±1.1	8.75	<0.01**	0.85	23.21±0.01	26.6±0.9	28.87±2.2	4.66	<0.05*	0,79	0.99
Nucleus/cytoplasmratio	0.81±2.0	0.78±0.01	0.26	0.614	0.15	0.81±2.0	0.77±0.1	0.80±0.1	0.23	0.794	0,21	0.05
Areaofmitochondria(μm2)	1.31±0.1	0.75±0.1	30.53	<0.001***	1.26	1.31±0.1	0.76±0.1	0.74±0.1	15.10	<0.001***	1,23	1.35
Vvofmitochondria (%)	5.88±3.1	2.75±0.3	42.67	<0.001***	1.39	5.88±3.1	2.9±0.5	2.56±0.3	20.84	<0.001***	1,31	1.48
N ofmitochondria	2.70±1.6	1.52±0.1	35.45	<0.001***	1.31	2.70±1.6	1.53±0.2	1.50±0.2	17.52	<0.001***	1,27	1.43
Areaofvacuoles (μm2)	0.28±2.2	0.84±0.2	8.83	<0.01**	1.02	0.28±2.2	0.83±0.3	0.84±0.2	4.24	<0.05*	1,06	1.06
Vvofvacuoles (%)	0.80±0.2	2.01±0.5	3.64	0.065	0.64	0.80±0.2	1.66±0.7	2.47±0.7	2.81	0.074	0,45	0.95
N ofvacuoles	0.32±0.3	0.84±0.2	4.17	<0.05*	0.65	0.32±0.3	0.48±0.2	1.31±0.4	7.09	<0.01**	0,34	1.13
Area of lipofuscin granules (μm2)	0.32±0.01	0.91±0.1	28.62	<0.001***	1.33	0.32±0.01	0.94±0.1	0.88±0.1	14.06	<0.001***	1,35	1.59
Vvoflipofuscingranules (%)	1.18±0.1	3.43±0.4	30.51	<0.001***	1.32	1.18±0.1	3.62±0.6	3.17±0.4	15.45	<0.001***	1,38	1.55
N oflipofuscingranules	0.21±0.1	0.63±0.1	33.22	<0.001***	1.37	0.21±0.1	0.68±0.1	0.54±0.1	18.37	<0.001***	1,45	1.57
Cell density (N /mm2)	59.04±4.4	67.75±5.2	1.25	0.271	0.38	59.04±4.4	66.42±8.5	69.53±5.0	0.73	0.487	0,30	0.54

*p < 0.05, **p < 0.01, ***p < 0.001.