Table 2.
Microglia adjacent to oligodendrocytes | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Controls (n=20) | Schizophrenia (n=21) | F(1,37) | p | Cohen’s d | Controls (n=20) | SPPS (n=12) | SPNS (n=9) | F(2,36) | p | Cohen’s d | ||
Mean±SEM | Mean±SEM | Mean±SEM | Mean±SEM | Mean±SEM | SPPS/ Controls | SPNS/ Controls | ||||||
Areaofmicroglia(μm2) | 18.92±0.01 | 19.61±0.9 | 0.26 | 0.615 | 0.20 | 18.92±0.01 | 18.95±0.9 | 20.49±1.7 | 0.88 | 0.424 | 0,01 | 0.43 |
Areaofnucleus (μm2) | 10.14±3.6 | 10.19±0.5 | <0.00 | 0.985 | 0.03 | 10.14±3.6 | 10.01±0.4 | 10.43±1.0 | 0.04 | 0.956 | 0,09 | 0.15 |
Areaofcytoplasm(μm2) | 8.78±0.3 | 9.42±0.7 | 0.42 | 0.522 | 0.24 | 8.78±0.3 | 8.93±0.7 | 10.07±1.3 | 1.19 | 0.315 | 0,07 | 0.45 |
Nucleus/cytoplasmratio | 1.95±1.7 | 1.95±0.2 | 0.01 | 0.913 | 0.01 | 1.95±1.7 | 1.95±0.3 | 1.96±0.3 | 0.15 | 0.863 | 0,00 | 0.02 |
Areaofmitochondria (μm2) | 0.90±1.0 | 0.38±0.01 | 29.47 | <0.001*** | 1.33 | 0.90±1.0 | 0.35±0.1 | 0.40±0.1 | 14.56 | <0.001*** | 1,34 | 1.27 |
Vvofmitochondria (%) | 10.15±1.3 | 3.77±0.5 | 50.98 | <0.001*** | 1.50 | 10.15±1.3 | 3.37±0.8 | 4.31±0.7 | 25.33 | <0.001*** | 1,53 | 1.49 |
N ofmitochondria | 1.68±0.2 | 0.65±0.1 | 33.91 | <0.001*** | 1.36 | 1.68±0.2 | 0.54±0.1 | 0.80±0.2 | 17.60 | <0.001*** | 1,44 | 1.23 |
Areaofvacuoles (μm2) | 0.85±0.7 | 1.57±0.2 | 7.27 | <0.05* | 0.77 | 0.85±0.7 | 1.69±0.3 | 1.41±0.3 | 4.11 | <0.05* | 0,88 | 0.76 |
Vvofvacuoles (%) | 9.25±0.01 | 17.54±2.5 | 9.79 | <0.01** | 0.83 | 9.25±0.01 | 19.51±3.7 | 14.91±3.2 | 6.35 | <0.01** | 1,01 | 0.77 |
N ofvacuoles | 1.70±0.1 | 3.20±0.5 | 6.19 | <0.05* | 0.72 | 1.70±0.1 | 3.48±0.8 | 2.81±0.7 | 3.75 | <0.05* | 0,84 | 0.67 |
Area of lipofuscin granules μm2) | 0.21±0.1 | 0.56±0.1 | 11.96 | <0.01** | 1.09 | 0.21±0.1 | 0.61±0.1 | 0.49±0.1 | 5.81 | <0.01** | 1,28 | 1.08 |
Vvoflipofuscingranules (%) | 1.80±1.0 | 5.28±0.9 | 13.10 | <0.001*** | 0.99 | 1.8±1.0 | 6.03±1.3 | 4.29±1.0 | 7.01 | <0.01** | 1,15 | 0.99 |
N oflipofuscingranules | 0.11±0.2 | 0.32±0.1 | 9.95 | <0.01** | 0.90 | 0.11±0.2 | 0.30±0.1 | 0.33±0.1 | 5.37 | <0.01** | 1,06 | 0.99 |
Cell density (N /mm2) | 59.97±4.1 | 69.88±5.4 | 1.50 | 0.228 | 0.42 | 59.97±4.1 | 70.04±8.8 | 69.67±5.3 | 0.75 | 0.478 | 0,40 | 0.48 |
Oligodendrocytes adjacent to microglia | ||||||||||||
Areaofoligodendrocyte(μm2) | 38.87±0.7 | 45.97±1.8 | 9.34 | <0.01** | 0.87 | 38.87±0.7 | 43.84±2.0 | 48.8±3.1 | 5.50 | <0.01** | 0,71 | 1.15 |
Areaofnucleus (μm2) | 15.67±5.3 | 18.4±1.0 | 3.79 | 0.059 | 0.60 | 15.67±5.3 | 17.25±1.3 | 19.93±1.6 | 2.60 | 0.088 | 0,38 | 0.91 |
Areaofcytoplasm (μm2) | 23.21±0.01 | 27.57±1.1 | 8.75 | <0.01** | 0.85 | 23.21±0.01 | 26.6±0.9 | 28.87±2.2 | 4.66 | <0.05* | 0,79 | 0.99 |
Nucleus/cytoplasmratio | 0.81±2.0 | 0.78±0.01 | 0.26 | 0.614 | 0.15 | 0.81±2.0 | 0.77±0.1 | 0.80±0.1 | 0.23 | 0.794 | 0,21 | 0.05 |
Areaofmitochondria(μm2) | 1.31±0.1 | 0.75±0.1 | 30.53 | <0.001*** | 1.26 | 1.31±0.1 | 0.76±0.1 | 0.74±0.1 | 15.10 | <0.001*** | 1,23 | 1.35 |
Vvofmitochondria (%) | 5.88±3.1 | 2.75±0.3 | 42.67 | <0.001*** | 1.39 | 5.88±3.1 | 2.9±0.5 | 2.56±0.3 | 20.84 | <0.001*** | 1,31 | 1.48 |
N ofmitochondria | 2.70±1.6 | 1.52±0.1 | 35.45 | <0.001*** | 1.31 | 2.70±1.6 | 1.53±0.2 | 1.50±0.2 | 17.52 | <0.001*** | 1,27 | 1.43 |
Areaofvacuoles (μm2) | 0.28±2.2 | 0.84±0.2 | 8.83 | <0.01** | 1.02 | 0.28±2.2 | 0.83±0.3 | 0.84±0.2 | 4.24 | <0.05* | 1,06 | 1.06 |
Vvofvacuoles (%) | 0.80±0.2 | 2.01±0.5 | 3.64 | 0.065 | 0.64 | 0.80±0.2 | 1.66±0.7 | 2.47±0.7 | 2.81 | 0.074 | 0,45 | 0.95 |
N ofvacuoles | 0.32±0.3 | 0.84±0.2 | 4.17 | <0.05* | 0.65 | 0.32±0.3 | 0.48±0.2 | 1.31±0.4 | 7.09 | <0.01** | 0,34 | 1.13 |
Area of lipofuscin granules (μm2) | 0.32±0.01 | 0.91±0.1 | 28.62 | <0.001*** | 1.33 | 0.32±0.01 | 0.94±0.1 | 0.88±0.1 | 14.06 | <0.001*** | 1,35 | 1.59 |
Vvoflipofuscingranules (%) | 1.18±0.1 | 3.43±0.4 | 30.51 | <0.001*** | 1.32 | 1.18±0.1 | 3.62±0.6 | 3.17±0.4 | 15.45 | <0.001*** | 1,38 | 1.55 |
N oflipofuscingranules | 0.21±0.1 | 0.63±0.1 | 33.22 | <0.001*** | 1.37 | 0.21±0.1 | 0.68±0.1 | 0.54±0.1 | 18.37 | <0.001*** | 1,45 | 1.57 |
Cell density (N /mm2) | 59.04±4.4 | 67.75±5.2 | 1.25 | 0.271 | 0.38 | 59.04±4.4 | 66.42±8.5 | 69.53±5.0 | 0.73 | 0.487 | 0,30 | 0.54 |
*p < 0.05, **p < 0.01, ***p < 0.001.