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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Ann Neurol. 2019 Oct 2;86(5):671–682. doi: 10.1002/ana.25592

TABLE 4.

Unadjusted and Adjusted Linear Regression Analyses of Association of Change in Leukocyte Telomere Length with Longitudinal Clinical and Magnetic Resonance Imaging Outcomes in the Subset with Telomere Length Measured Longitudinally, Expressed per 0.2U Decrease in Telomere Length (n = 46)

Unadjusted Adjustedb
Outcomea βc 95% CI p βc 95% CI p
Disability score (EDSS) 0.31 0.05 to 0.57 0.021 0.34 0.08 to 0.61 0.012
MSFC z score 0.07 −0.03 to 0.17 0.15 0.08 −0.02 to 0.18 0.10
Total brain volume, mm3 −9.1 −20.6 to 2.4 0.12 −6.2 −17.6 to 5.2 0.29
Total WM volume, mm3 −3.4 −10.7 to 3.8 0.35 −2.4 −9.7 to 4.9 0.52
Total GM volume, mm3 −4.4 −11.3 to 2.6 0.22 −2.7 −9.3 to 4.0 0.44
Cortical GM volume, mm3 −0.55 −6.2 to 5.1 0.85 0.13 −5.4 to 5.7 0.96
a

n = 46. Each row represents a separate model.

b

Adjusted for baseline chronological age, sex, and disease duration.

c

Per 0.2U decrease in mean telomere to somatic DNA ratio (leukocyte telomere length).

CI = confidence interval; EDSS = Expanded Disability Status Scale; GM = gray matter; MSFC = multiple sclerosis functional composite; WM = white matter; β = linear regression coefficient.