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. Author manuscript; available in PMC: 2020 Aug 12.
Published in final edited form as: Nature. 2020 Feb 12;579(7800):575–580. doi: 10.1038/s41586-020-2039-9

Figure 4. Feeding reduces IL-22 production by CCR6+ILC3 through activation of VIPergic neurons.

Figure 4.

IL-22 expression among CCR6+ ILC3 from the ileum of mice, as indicated a, b, at 6h after feeding or fasting, at ZT6 and ZT18 (n=5 mice for each one of the 4 groups). From 2 independent experiments. c, d, RORc(t)CreVipr2+/+ (n=6) or RORc(t)CreVipr2fl/fl mice (n=6 mice) at 6h after fasting or 6h after feeding (n=7 mice for each) at ZT18. Data shown are pooled from 2 independent experiments and representative of 3 independent experiments. e, f, VipIRES-CrehM4Difl-stop-fl/+ mice were treated with vehicle or CNO and 30 minutes later were fed by intragastric administration of saline or Liquid Test Diet (every 45 minutes, for 6 h). n=4 mice/group. From 2 independent experiments. Data (b,d,f) are Mean ± SEM, two-sided t-test.