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Trp-110 elbow and C–D latch of PD-L2 evolved contemporaneously with placental mammal radiation. Phylogenetic analysis of the PD-L2 IgV domain. PD-L2 emerged from a gene duplication from a primordial PD-L1 between lobe-finned fish and amphibian divergence (blue hexagon). The Trp-110 elbow (red) and C–D latch (green) of PD-L2 emerged exclusively in placental mammals (red hexagon).
