Norrin restores blood-retinal barrier permeability in vivo.
A, Evans Blue accumulation in rat retinas with an IVT injection of vehicle, 40 ng of norrin, 50 ng of VEGF, or both (VEGF/norrin) for 24 h; n = 8–16. B, FITC-BSA accumulation in rat retinas of control (nondiabetic) or STZ-induced diabetic rats that were treated after 5 months with an IVT injection of vehicle or 40 ng of norrin for 24 h; n = 15–17. p values were calculated by one-way ANOVA, followed by Tukey's post hoc test (A) or t test analysis (B). Error bars, S.D.