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Tolerance Returning Post-Infection. With resolution, most clonally expanded T cells undergo apoptosis to restore the total number of cells to normal baseline. Phagocytosis of these dendritic cells (DCs) by macrophages and immature DCs generates TGF-b – that is important in switching DCs from immunogenic to mature tolerogenic cells. The steady-state is then ideally restored. Abbreviation: Treg, regulatory T cell.
