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Failure To Return to Steady-State Can Result in Autoimmunity. For multifactorial reasons, the failure of a homeostatic compensatory response (following e.g., infection) can result in the persistence of potentially pathogenic self-reactive cells triggered by infection, and might initiate autoimmune disease in susceptible individuals. Abbreviations: DE, dendritic cell; Th1/2/17, type 1/2/17 T helper cells; Treg, regulatory T cell.
