Figure 2. T-distributed Stochastic Neighbor Embedding (t-SNE) representation of the immunologic profiles of healthy controls and patients with relapsing-remitting MS under different disease-modifying treatments.

Representations, as depicted by t-SNE algorithm (n = 600,000 cells), of (A) total CD4⁺ and CD8⁺ T cells; (B) T-reg cells; (C) T-eff cells; (D) CD19⁺ B cells; and (E) NK cells. DMF = dimethyl fumarate; FINGO = fingolimod; GA = glatiramer acetate; HC = healthy control; IFN = interferon-β; NTZ = natalizumab; TERI = teriflunomide; UNT = untreated patients.