Figure 3. Predictive margins for Trail-Making Test (TMT), part A, by epigenetic clock 3 in male participants: mixed-effects regression model.

Epigenetic clock 3: extrinsic epigenetic age acceleration uses the Hannum et al. algorithm and combines epigenetic age acceleration with white blood cell proportion changes reflecting immunosenescence. Model 3 for TMT, part A (time to completion, in seconds), among men, table 3. 1 SD EpiClock3 ∼6.2 years.