Extended Data Fig. 6.

Power analysis and statistical simulation of case-control study.

Dot plot of frequencies of copy-number events and tumor purity in BM-LUAD (a) and TCGA-LUAD (b).

Correlations are measured by Kendall rank correlation coefficient. Blue curves represent LOESS regressions.

High-level amplification, > 8 total copy-number; Deep deletion, < 0.5 total copy-number;

Gain, > 3/2 normalized copy-ratio; Loss, < ½ normalized copy-ratio.

Normalized copy-ratio is total copy-number scaled to tumor ploidy.